At the beginning of the occupation of Pilsen, the synagogue was used as a storehouse for confiscated Jewish property. Later it was used as a factory to produce uniforms for German soldiers.

After World War II, it was returned to the Jewish community of Pilsen and used as a place of worship until 1973. In 1973 it was classified as a historic monument and was partially reconstructed. During the restoration, a bullet was discovered lodged into one of the tablets of the Ten Commandments next to “Thou shalt not kill” – a remnant of the battle to liberate the city in 1945.

Behind the synagogue in the park named after Pilsen-born actor Miroslav Horníček, a mini-memorial can be found made from the parts of the original pylons of the “Thank you, America!” memorial in central Pilsen.